Most investigators get their engineered mice from colleagues or by purchasing them from commercial outfits like JAX or academic-based repositories. Popular engineered mice, such as JAX’s immunodeficient NOD scid gamma strains, sell for as little as a few hundred dollars, but a custommade mutant could cost as much as $20,000. By making the engineering of mice far simpler and cheaper, CRISPR opens the way for more labs to do it themselves. “When you made knockout mice before, you needed some skills,” says Rudolf Jaenisch at the Massachusetts Institute of Technology (MIT) in Cambridge. “Now, you don’t need them anymore. Any idiot can do it.
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Salford Scientific Supplies
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